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US 12,703,738 B2Granted
Antibody constant region variant
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTomoyuki Igawa, Taichi Kuramochi, Atsuhiko Maeda, Hirotake Shiraiwa
Life of this patent
Estimating the term…
Abstract
Disclosed are IgG2 constant regions and human κ chain constant regions with altered amino acid sequences, antibodies comprising these constant regions, and pharmaceutical compositions comprising the antibodies.
Claims6
An antibody constant region comprising the amino acid sequence of SEQ ID NO:
- 24 with at least the following substitutions and optional deletions:
- Ser is substituted for Cys at position 14, which corresponds to EU numbering position 131;
- Lys is substituted for Arg at position 16, which corresponds to EU numbering position 133;
- Ser is substituted for Cys at position 103, which corresponds to EU numbering position 220;
- Gly is substituted for Glu at position 20, which corresponds to EU numbering position 137;
- Gly is substituted for Ser at position 21, which corresponds to EU numbering position 138;
- Gln is substituted for His at position 147, which corresponds to EU numbering position 268;
- Gln is substituted for Arg at position 234, which corresponds to EU numbering position 355;
- and
- Glu is substituted for Gln at position 298, which corresponds to EU numbering position 419,
- wherein Gly at position 325 and Lys at position 326 of SEQ ID NO:
- 24, corresponding to EU numbering positions 446 and 447, respectively, are optionally deleted.
9 more elements
An antibody constant region comprising the amino acid sequence of SEQ ID NO:
- 24 with at least the following substitutions and optional deletions:
- Ser is substituted for Cys at position 14, which corresponds to EU numbering position 131;
- Lys is substituted for Arg at position 16, which corresponds to EU numbering position 133;
- Ser is substituted for Cys at position 103, which corresponds to EU numbering position 220;
- Gly is substituted for Glu at position 20, which corresponds to EU numbering position 137;
- Gly is substituted for Ser at position 21, which corresponds to EU numbering position 138;
- Gln is substituted for His at position 147, which corresponds to EU numbering position 268;
- Gln is substituted for Arg at position 234, which corresponds to EU numbering position 355;
- Glu is substituted for Gln at position 298, which corresponds to EU numbering position 419;
- Ser is substituted for Ala at position 209, which corresponds to EU numbering position 330;
- Ser is substituted for Pro at position 210, which corresponds to EU numbering position 331;
- and
- Ala is substituted for Thr at position 218, which corresponds to EU numbering position 339,
- wherein Gly at position 325 and Lys at position 326 of SEQ ID NO:
- 24, corresponding to EU numbering positions 446 and 447, respectively, are optionally deleted.
12 more elements
Dependencies are inferred from the claim text.