BCAT modulation

A compound of Formula (I) or a pharmaceutically acceptable salt thereof:

• wherein
• Z is CH2, CF2, O, or a bond;
• each of J1, J2, J3, and J4 is independently CH or N;
• X1 is N or CR5A;
• X2 is N or CR5B;
• R1 is —NR3SO2R4, —NR3C(O)R4, or —C(O)(CH2)mNR3R4;
• R2 is —NR6R7, C3-C8 cycloalkyl, C6-C10 aryl, or 5-10 membered heteroaryl, wherein each aryl or heteroaryl is optionally substituted with one, two, or three substituents R2′ independently selected from halo, —CN, —NO2, C1-C6 alkyl, C1-C6 alkoxy, haloC1-C6 alkyl, haloC1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, —C(O)NR6R7, —C(O)R6, —NR6R7, —NR6C(O)R7, —OH, —S-(haloC1-C6 alkyl), C6-C10 aryl, and 5-10 membered heterocyclyl;
• or two R2′ substituents together with the atoms to which they are attached form a five-membered heterocyclyl or C3-C8 cycloalkyl, each optionally substituted with halo;
• R3 is H or methyl;
• R4 is phenyl, thiophene, oxazole, isoxazole, thiazole, furan, pyrrole, or C2-C6 alkenyl, wherein each phenyl, thiophene, oxazole, isoxazole, thiazole, furan, or pyrrole is optionally substituted with one, two, or three substituents R4′ independently selected from halo, —CN, —NO2, C1-C6 alkyl, haloC1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C3-C8 cycloalkyl, C6-C10 aryl, —(CH2)qNR8C(O)R9, —C(O)NR8R9, —C(O)OR9, —C(O)R9, and 5-10 membered heterocyclyl;
• R5A is F;
• R5B is H, halo, —CN, C1-C6 alkyl, haloC1-C6 alkyl, C1-C6 alkoxy, —(CH2), OH, —C(O)NR8R9, —NR8COR9, 5-10 membered heteroaryl, —C(O)R8, or —C(O)OR8;
• or R5A and R5B together with the atoms to which they are attached form a six-membered heterocyclyl ring optionally substituted with oxo;
• R6 and R7 are independently H, C1-C6 alkyl, or C3-C8 cycloalkyl;
• each R8 is independently H, C1-C6 alkyl, or C3-C8 cycloalkyl;
• each R9 is independently H, C1-C6 alkyl, C2-C6 alkenyl, or C3-C8 cycloalkyl;
• m is 0;
• q is 0 or 1;
• and
• r is 0 or 1.