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US 12,703,696 B2Granted
Diacylglycerol acyl transferase 2 inhibitors
AssigneePfizer Inc.
InventorsMarkus Boehm, Shawn Cabral, Matthew S. Dowling, Kentaro Futatsugi, Kim Huard, Esther Cheng Yin Lee, Allyn T. Londregan, Jana Polivkova, David A. Price, Qifang Li
Life of this patent
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Abstract
Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.
Claims15
A method for reduction of triglyceride level in a human, wherein the method comprises a step of administering to the human in need of such reduction an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt of said compound, wherein the compound of Formula (I) is:
- wherein
- D1 and D2 are each independently N or CH;
- R1 is H, or (C1-C2)alkyl optionally substituted with one or two substituents each independently selected from fluoro and (C3-C6) cycloalkyl;
- R2 is H or fluoro;
- R3 is
- R4 is H, cyano, or (C1-C4)alkyl optionally substituted with one or two substituents each independently selected from —OH and —S(O)2R6;
- R5 is H or —OH;
- and
- R6 is (C1-C4)alkyl.
6 more elements
Dependencies are inferred from the claim text.