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US 12,703,692 B2Granted
Small molecule inhibitors of mammalian SLC6A19 function
AssigneeJnana Therapeutics Inc.
InventorsDean G. Brown, Giovanni Muncipinto, Joshua Ethan Zweig, Long Vo Nguyen, Mitchell T. Antalek, Ryan A. Hollibaugh
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Abstract
Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with abnormal levels of amino acids by modulation of SLC6A19 transport.
Claims30
A compound of Formula (I):
- wherein:
- n is 1;
- L1 is -alkyl-;
- L2 is absent;
- L3 is —C(O)—;
- X1 and X2 are independently selected from —H and cycloalkyl;
- provided that X1 and X2 are not both —H;
- Y1 is unsubstituted or substituted aryl;
- Y2 is selected from hydroxyalkyl and —NH(Y2′);
- Y2′ is alkyl;
- and
- Y3, Y4, Y5, and Y6 are independently selected from —H, and halide;
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.