Crystalline form of sofpironium bromide and preparation method thereof
AssigneesKaken Pharmaceutical Co., Ltd., Brickell Biotech, Inc.
InventorsKazuyoshi Marubayashi, Masahito Watanabe, Herbert R. Brinkman
Life of this patent
Estimating the term…
Abstract
A cocrystal containing the 1′R-diastereomer and the 1′S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1′R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.
Claims7
A stable crystal Form MN of a compound shown as formula I-a
- characterized by showing peaks at 7.1±0.1, 21.4±0.1, 22.3±0.1, and 24.5±0.1 as diffraction angles 2θ in a powder X-ray diffraction spectrum.
Dependencies are inferred from the claim text.