Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications
AssigneeCura Therapeutics, LLC
InventorsNazneen Dewji, Darryl Rideout, Gerard Rosse
Life of this patent
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Abstract
Provided herein are sulfone compounds, for example, a compound of Formula A, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof; and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disorder, disease, or condition.
Claims23
A method of inhibiting the production of amyloid β in a subject in need thereof, the method comprising administering to said subject an effective amount of a compound chosen from compounds of Formula I(a) and pharmaceutically acceptable salts thereof:
- wherein, in Formula I(a):
- X is —SO2—;
- Y is —CH2— or —NH—;
- R3 and R5 are independently chosen from hydrogen, —NR1aS(O)2R1d, —C(RA)—, optionally substituted C1-6 alkyl, and optionally substituted C1-6 alkoxy, with the proviso that if R3 or R5 is optionally substituted C1-6 alkyl or optionally substituted C1-6 alkoxy, the substituent(s) are fluoro;
- RA is —S(O)2R1a;
- and
- R1a, R1d, R2, R4, and R6 are independently chosen from hydrogen and C1-6 alkyl.
A method of inhibiting the production of amyloid β in a cell, the method comprising contacting said cell with an effective amount of a compound chosen from compounds of Formula I(a) and pharmaceutically acceptable salts thereof:
- wherein, in Formula I(a):
- X is —SO2—;
- Y is —CH2— or —NH—;
- R3 and R5 are independently chosen from hydrogen, —NR1aS(O)2R1d, —C(RA)—, optionally substituted C1-6 alkyl, and optionally substituted C1-6 alkoxy, with the proviso that if R3 or R5 is optionally substituted C1-6 alkyl or optionally substituted C1-6 alkoxy, the substituent(s) are fluoro;
- RA is —S(O)2R1a;
- and
- R1a, R1d, R2, R4, and R6 are independently chosen from hydrogen and C1-6 alkyl.
Dependencies are inferred from the claim text.