Method and system for combining anatomical connectivity patterns and navigated brain stimulation
AssigneeNexstim Oyj
InventorsTuomas Neuvonen, Henri Hannula
Life of this patent
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Abstract
When operating a brain stimulation device, it is critical to understand and control the network effects associated with the area being targeted for stimulation. The combined system and methods provided herein provides the operator with a real-time view of the brain network potentially affected by the stimulation. The system and method are capable of increasing the accuracy of diagnostic information. Additionally, disclosed herein are a system and method for combining navigated brain stimulation data and anatomical data with brain connectivity data for an individual.
Claims24
A method for combining non-invasive transcranial stimulation navigation with functional data, said method comprising the steps of;
- acquiring an anatomical image of a brain,
- acquiring functional data of the brain,
- coregistering at least a portion of the functional data, said portion being associated with a portion of interest of the brain, with a corresponding location from the anatomical image in order to form a combined view of the brain,
- stereotactically aligning the combined view of the brain and a transcranial magnetic stimulation (TMS) stimulation device in real-time,
- providing a view of the combined view of the brain containing a real-time indication on a brain network potentially affected by stimulation based on the stereotactically aligned combined view of the brain and the TMS stimulation device,
- identifying a first region of interest of the brain associated with a particular function,
- identifying a second region of interest of the brain intracranially connected to said first region based at least on the combined view and navigated TMS mapping data, and
- indirectly stimulating the first region of interest of the brain by applying stimulation to the second region of interest of the brain.
A non-transitory computer readable medium having stored there on a set of computer readable instructions for causing one or more processors to carry out the steps of:
- acquiring an anatomical image of a brain,
- acquiring functional data of the brain,
- coregistering at least a portion of the functional data, said portion being associated with a portion of interest of the brain, with a corresponding location from the anatomical image in order to form a combined view of the brain,
- stereotactically aligning the combined view of the brain and a transcranial magnetic stimulation (TMS) stimulation device in real-time,
- providing a view of the combined view of the brain containing a real-time indication on a brain network potentially affected by stimulation based on the stereotactically aligned combined view of the brain and the TMS stimulation device,
- identifying a first region of interest of the brain associated with a particular function,
- identifying a second region of interest of the brain intracranially connected to said first region based at least on the combined view and navigated TMS mapping data, and
- indirectly stimulating the first region of interest of the brain by applying stimulation to the second region of interest of the brain.
A computer assisted stereotactic positioning system and transcranial magnetic stimulation (TMS) system comprising:
- a TMS stimulation device,
- a stereotactic arrangement connected to the TMS stimulation device in order to guide the TMS stimulation device,
- non-transitory computer readable medium having stored there on a set of computer readable instructions for causing one or more processors to carry out the steps of:
- acquiring an anatomical image of a brain,
- acquiring functional data of the brain,
- coregistering at least a portion of the functional data, said portion being associated with a portion of interest of the brain, with a corresponding location from the anatomical image in order to form a combined view of the brain,
- stereotactically aligning the combined view of the brain and the TMS stimulation device in real-time in order to create a stereotactic frame for use in guiding the TMS stimulation device via the stereotactic arrangement,
- providing a view of the combined view of the brain containing a real-time indication on a brain network potentially affected by stimulation based on the stereotactically aligned combined view of the brain and the TMS stimulation device,
- identifying a first region of interest of the brain associated with a particular function,
- identifying a second region of interest of the brain intracranially connected to said first region based at least on the combined view and navigated TMS mapping data, and
- indirectly stimulating the first region of interest of the brain by applying stimulation to the second region of interest of the brain,
- wherein the system is configured to provide said indication on the brain network potentially affected by stimulation in real-time during stimulation.
Dependencies are inferred from the claim text.