Systems and methods for evaluating neuromodulation based on evoked potentials
AssigneeDuke University
InventorsIsaac Cassar, Warren Grill
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Abstract
The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for evaluating the efficacy of neuromodulation therapy using evoked potential (EPs). The systems and methods disclosed herein facilitate the evaluation of both parameter-dependent and system-dependent changes in EPs as indicators of therapeutic efficacy.
Claims23
A method of determining efficacy of a neuromodulation therapy based on evoked potential (EP), the method comprising:
- (i) administering a first functional stimulation train superimposed with a second probe stimulation train to neural tissue of a subject according to stimulation parameter settings, and obtaining a reference EP recording from the subject;
- and
- (ii) altering at least one stimulation parameter of the first functional stimulation train with respect to the reference EP recording, and obtaining a variable EP recording from the subject;
- wherein at least one different feature of the variable EP recording obtained by altering the at least one stimulation parameter correlates with a disease indication, a change in symptom, and/or a change in a side effect;
- and
- wherein activation during stimulation of the subject's neural tissue for each of the reference EP recording and the variable EP recording is quantified on a per-second basis by summing individual responses to multiple repetitions of pulses within a stimulation train during a specified interval of time.
A method of determining efficacy of a neuromodulation therapy based on evoked potential (EP), the method comprising:
- (i) administering a first functional stimulation train superimposed with a second probe stimulation train to neural tissue of a subject according to stimulation parameter settings, and obtaining a reference EP recording from the subject;
- and
- (ii) obtaining a variable EP recording from the subject using stimulation parameters for the second probe stimulation train that are identical with respect to the reference EP recording;
- wherein at least one different feature of the variable EP recording correlates with a disease indication, a change in symptom, and/or a change in a side effect;
- and
- wherein activation during stimulation of the subject's neural tissue for each of the reference EP recording and the variable EP recording is quantified on a per-second basis by summing individual responses to multiple repetitions of pulses within a stimulation train during a specified interval of time.
A method of determining efficacy of a neuromodulation therapy based on evoked potential (EP), the method comprising:
- (i) administering a first functional stimulation train superimposed with a second probe stimulation train to neural tissue of a subject according to stimulation parameter settings to obtain a reference EP recording;
- and
- (ii) altering at least one stimulation parameter of the first functional stimulation train with respect to the reference EP recording to obtain a first variable EP recording;
- and obtaining a second variable EP recording using stimulation parameters for the second probe stimulation train that are identical with respect to the reference EP recording;
- wherein at least one different feature of the first and/or second variable EP recording correlates with a disease indication, a change in symptom, and/or a change in a side effect.
Dependencies are inferred from the claim text.