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US 12,702,841 B2Granted
Electrical stimulation entrainment of targeted neuronal cell types
AssigneeAllen Institute
InventorsConstantinos Anastassiou, Soo Yeun Lee
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AssigneeAllen Institute
InventorsConstantinos Anastassiou, Soo Yeun Lee
Estimating the term…
Electrostimulating waveforms offering simultaneous and controllable cell-type-specific entrainment are described. The waveforms selectively entrain excitatory versus inhibitory cortical and hippocampal neurons including pyramidal neurons, parvalbumin neurons, and somatostatin neurons. The embodiment provides targeted electrical stimulation (ES) entrainment of excitatory versus inhibitory neurons. For example, the current disclosure provides methods of selectively entraining excitatory neurons with ES frequencies below 30 Hertz (Hz) and in particular embodiments to frequencies below 15 Hz, such as 8 Hz and 4 Hz. The current disclosure also provides methods of selectively entraining inhibitory neurons to ES frequencies of at least 30 Hz and depending on the type of inhibitory neuron, utilizing a frequency that is 30-60 Hz or a frequency that is greater than 100 Hz.
A method comprising delivering electrical stimulation(ES) at a first frequency and a second frequency to a brain of a subject wherein the ES having the first frequency entrains a first selected cell type and the ES having the second frequency entrain a second selected cell type, and wherein the first frequency is greater than zero and less than 30 Hertz (Hz) and the first selected cell type is an excitatory neuron, and the second frequency is 30 Hz or greater and the second selected cell type is an inhibitory neuron.
A method comprising entraining excitatory pyramidal cortical neurons within a primary visual cortex while simultaneously entraining inhibitory cortical neurons within the primary visual cortex in a brain of a subject, the method comprising:
Dependencies are inferred from the claim text.