Evoked signal based deep brain stimulation (DBS) programming

A method for therapy parameter determination, the method comprising:

• delivering, with stimulation generation circuitry, a first plurality of electrical stimulation signals, wherein a frequency of each electrical stimulation signal of the first plurality of electrical stimulation signals is lower than a threshold frequency, and an amplitude or pulse width of a first electrical stimulation signal of the first plurality of electrical stimulation signals is different than an amplitude or pulse width of a second electrical stimulation signal of the first plurality of electrical stimulation signals, and wherein delivery of each of the first plurality of electrical stimulation signals evokes a respective evoked potential signal of a plurality of evoked potential signals;
• delivering, with the stimulation generation circuitry, a second plurality of electrical stimulation signals, wherein a frequency of a first electrical stimulation signal of the second plurality of electrical stimulation signals is different than a frequency of a second electrical stimulation signal of the second plurality of electrical stimulation signals, and wherein delivery of each of the second plurality of electrical stimulation signals evokes a respective evoked resonant neural activity (ERNA) signal of a plurality of ERNA signals;
• determining at least one of an amplitude or pulse width of a therapeutic electrical stimulation signal and a frequency of the therapeutic electrical stimulation signal, wherein the amplitude or pulse width of the therapeutic electrical stimulation signal is determined based on the evoked potential signals, and wherein the frequency of the therapeutic electrical stimulation signal is determined based on the ERNA signals;
• and
• delivering, with the stimulation generation circuitry, the therapeutic electrical stimulation signal.

A computer-readable storage medium storing instructions thereon that when executed cause one or more processors to:

• deliver, with stimulation generation circuitry, a first plurality of electrical stimulation signals, wherein a frequency of each electrical stimulation signal of the first plurality of electrical stimulation signals is lower than a threshold frequency, and an amplitude or pulse width of a first electrical stimulation signal of the first plurality of electrical stimulation signals is different than an amplitude or pulse width of a second electrical stimulation signal of the first plurality of electrical stimulation signals, and wherein delivery of each of the first plurality of electrical stimulation signals evokes a respective evoked potential signal of a plurality of evoked potential signals;
• deliver, with the stimulation generation circuitry, a second plurality of electrical stimulation signals, wherein a frequency of a first electrical stimulation signal of the second plurality of electrical stimulation signals is different than a frequency of a second electrical stimulation signal of the second plurality of electrical stimulation signals, and wherein delivery of each of the second plurality of electrical stimulation signals evokes a respective evoked resonant neural activity (ERNA) signal of a plurality of ERNA signals;
• determine at least one of an amplitude or pulse width of a therapeutic electrical stimulation signal and a frequency of the therapeutic electrical stimulation signal, wherein the amplitude or pulse width of the therapeutic electrical stimulation signal is determined based on the evoked potential signals, and wherein the frequency of the therapeutic electrical stimulation signal is determined based on the ERNA signals;
• and
• deliver, with the stimulation generation circuitry, the therapeutic electrical stimulation signal.