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US 12,702,718 B2Granted
Protein-enclosing polymeric micelle
AssigneeThe University of Tokyo
InventorsHoracio Cabral, Anqi Tao, Kazunori Igarashi, Takuya Miyazaki, George Lo Huang, Pengwen Chen
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Abstract
The present invention provides a polymeric complex comprising a protein and a block copolymer represented by the following formula (1).
Claims7
A polymeric complex comprising a protein and a block copolymer represented by the following formula (1):
- wherein R1 represents an optionally substituted linear or branched alkyl group containing 1 to 12 carbon atoms and R2 represents a hydrogen atom,
- R3 represents a compound represented by the following formula (Ia) or (Ib),
- L1 represents NH or a group represented by the following formula (11):
- -(CH2)p1-NH- (11),
- wherein p1 represents an integer of 1 to 6,
- m1 and m2 each represent an integer of 0 to 500, provided that the sum of m1 and m2 represents an integer of 10 to 500, and with the proviso that m1 is not 0 and m2 is not 0,
- m3, m4 and m5 each independently represent an integer of 1 to 5, and n represents an integer of 1 to 500, and
- the symbol “/” means that (m1+m2) units of the respective monomer units shown on the left and right sides of this symbol may be in any sequence.
5 more elements
A protein delivery kit comprising a block copolymer represented by the following formula (1) for use in protein delivery to any site selected from a cell surface site, an intracellular site and an extracellular site:
- wherein R1 represents an optionally substituted linear or branched alkyl group containing 1 to 12 carbon atoms and R2 represents a hydrogen atom,
- R3 represents a compound represented by the following formula (Ia) or (Ib),
- L1 represents NH or a group represented by the following formula (11):
- —(CH2)p1-NH- (11)
- wherein p1 represents an integer of 1 to 6,
- m1 and m2 each independently represent an integer of 0 to 500 provided that the sum of m1 and m2 represents an integer of 1 to 500 and with the proviso that m1 is not 0 and m2 is not 0,
- m3, m4 and m5 each independently represent an integer of 1 to 5, and n represents an integer of 1 to 500, and
- the symbol “/” means that (m1+m2) units of the respective monomer units shown on the left and right sides of this symbol may be in any sequence.
5 more elements
Dependencies are inferred from the claim text.