Monocyte-specific aptamers and uses thereof for delivering therapeutic agents to heart
AssigneeAcademia Sinica
InventorsPatrick Ch Hsieh, Hsien-Ming Lee, Keng-Jung Lee, Hung-Chih Chen
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Abstract
Monocyte-specific nucleic acid aptamers and lipid nanoparticles comprising such for use in drug delivery. Also disclosed herein are use of the aptamer-based lipid nanoparticle drug delivery system for treating heart injury.
Claims17
A lipid nanoparticle capable of delivering an agent to a heart site, comprising a nucleic acid aptamer, and an agent capable of treating or diagnosing a heart injury, wherein the nucleic acid aptamer is attached to the lipid nanoparticle and the agent is encapsulated by the lipid nanoparticle, and wherein the nucleic acid aptamer comprises a core nucleotide sequence at least 85% identical to 5′-GGA TGG GAG GGA GGG GGC TCG TGG CGG CTA GGG GGT ATA A-3′ (SEQ ID NO:1).
Dependencies are inferred from the claim text.