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US 12,702,713 B2Granted
Semi-solid, oil-based pharmaceutical compositions containing pirfenidone for application in tissue repair
AssigneeExcalibur Pharmaceuticals, Inc.
InventorsJuan Armendáriz Borunda, José Agustín Rogelio Magaña Castro, Laura Vázquez Cervantes
Life of this patent
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Abstract
The present invention describes semi-solid pharmaceutical compositions containing Pirfenidone, which offer advantages over other cutaneously administered pharmaceutical forms known in the prior art, due to its permeability and absorption characteristics, which are useful in the treatment for restoring tissues that have suffered loss or degradation of extracellular matrix resulting in the formation of wrinkles or skin thinning.
Claims7
A semi-solid pirfenidone pharmaceutical composition comprising:
- (a) from 2% to 12% w/w pirfenidone;
- (b) from 20% to 60% w/w of propylene glycol;
- (c) from 5% to 10% w/w total of one or more of sorbitan stearate, ceteareth-6 and stearyl alcohol, ceteareth-25, and polysorbate 60;
- (d) from 2% to 8% w/w total of one or more of cetyl alcohol and stearyl alcohol;
- (e) from 0.5% to 3% w/w of one or more dimethicone;
- (f) from 0.1% to 2% w/w of sodium methylparaben;
- (g) from 0.05% to 0.2% w/w of carbomer;
- (h) from 0.05% to 0.2% w/w of triethanolamine;
- (i) from 0.05% to 0.2% w/w of sodium propylparaben;
- and
- (j) from 0.0005% to 0.003% w/w of citric acid;
- wherein the semi-solid pharmaceutical composition is in the form of a cream.
9 more elements
Dependencies are inferred from the claim text.