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US 12,702,712 B2Granted
Enteroendocrine cell-targeting polymer substance conjugated with photosensitizer, and medical use thereof for ameliorating metabolic disease
AssigneeThe Catholic University of Korea Industry-Academic Cooperation Foundation
InventorsKun Na, Sang Hee Lee
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Abstract
A fatty acid-biocompatible polymer-photosensitizer conjugate is provided. The conjugate can kill GIP-secreting cells by generating active oxygen upon irradiation with light, and has the effect of increasing insulin, and thus can be effectively used for ameliorating and treating metabolic diseases such as obesity and diabetes.
Claims5
A method for treating a metabolic disease, comprising administering to an individual in need of treatment a conjugate comprising:
- (a) oleic acid;
- (b) a biocompatible polymer covalently linked to the oleic acid and selected from the group consisting of PEG, chitosan, and pullulan;
- and
- (c) a photosensitizer linked to the biocompatible polymer via a covalent bond.
1 more element
Dependencies are inferred from the claim text.