Presenting cell and use thereof in cell therapy
AssigneesInnovative Cellular Therapeutics Holdings, Ltd., Innovative Cellular Therapeutics, Inc.
InventorsLei Xiao, Chengfei Pu, Zhiyuan Cao, Zhao Wu, Le Tian
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Abstract
The present disclosure relates to compositions and methods for enhancing T cell response and/or CAR cell expansion and/or maintenance in vivo and/or in vitro. For example, in a method of in vivo cell expansion, the method comprises administering an effective amount of cells comprising an antigen binding molecule to a subject; and administering an effective amount of presenting cells expressing a solid tumor antigen that the binding molecule binds.
Claims21
A method of expanding lymphocytes or enhancing expansion of lymphocytes, the method comprising:
- administering an effective amount of lymphocytes to a subject having a solid tumor;
- administering an effective amount of an agent to the subject, wherein the agent stimulates or activates antigen presenting cells (APCs) of the subject, and wherein the agent comprises a chimeric antigen receptor (CAR) T cell binding a B cell, a bispecific antibody binding a B cell and a T cell, an antibody binding a B cell, or a combination thereof;
- and
- allowing the lymphocytes to expand in the subject.
A method of expanding T cells or enhancing expansion of T cells, the method comprising:
- administering an effective amount of T cells to a subject having solid tumor;
- administering an effective amount of an agent to the subject, wherein the agent stimulates or activates B cells of the subject, and wherein the agent comprises a CAR T cell binding a B cell, a bispecific antibody binding a B cell and a T cell, an antibody binding a B cell, or a combination thereof;
- and
- allowing the T cells to expand in the subject.
Dependencies are inferred from the claim text.