Compositions and methods for treatment of headache disorders and neuropathic pain
AssigneeWashington University
InventorsYu-Qing Cao, Zhiyu Zhang, Rong Hu, Jintao Zhang, Megan E. Cloud
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Abstract
Among the various aspects of the present disclosure is the provision of compositions and methods of treating or preventing various headache disorders or neuropathic pain by increasing the number of Treg cells in a subject. In particular, low dose IL-2, rapamycin, statin or Treg cell administration are shown to be useful in treating or preventing headache or neuropathic pain.
Claims9
A method of treating a headache in a subject in need thereof, the method comprising, systemically administering a composition comprising Interleukin-2 (IL-2) at a dose of about 0.05 MIU/m2/day to less than 3.5 MIU/m2/day that increases the amount of Treg cells in the subject daily for at least 6 days, wherein at least one symptom of the headache is reduced.
Dependencies are inferred from the claim text.