Methods and composition for modulating immune response and immune homeostasis
AssigneesMassachusetts Institute of Technology, President and Fellows of Harvard College
InventorsCarly G.K. Ziegler, Siyi Huang, Ulrich H. von Andrian, Alexander K. Shalek
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Abstract
The present invention discloses novel methods, uses thereof, and compositions for modulating immune responses and homeostasis in a lymph node (LN). Moreover, structural and molecular characteristics of LN-innervating sensory neurons are provided. The present invention also discloses the target cells for LN-innervating sensory neurons in LN and molecular profiles of these target cells. These molecular characteristics provide therapeutic targets for modulating immune response and immune homeostasis in LN in an animal or a human.
Claims7
A method of acquiring or maintaining lymph node (LN) homeostasis in skin-draining LNs, comprising
- administering a genetic modifying agent comprising a CRISPR-Cas protein and a guide RNA capable of forming a complex with the CRISPR-Cas protein and directing sequence-specific binding to the Calca gene encoding the protein of SEQ ID NO:
- 1 to a skin-draining LN of a subject with an autoimmune or inflammatory disease,
- wherein the genetic modifying agent modulates neural stimulation and/or efferent signaling of LN-innervating peptidergic nociceptor sensory neurons by regulating Calca expression or function.
Dependencies are inferred from the claim text.