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US 12,702,685 B2Granted
Attenuated Salmonella gallinarum expressing FliC or FliC-hIL2 and uses thereof
AssigneeOdysseus Bio Co., Ltd.
InventorsKwangsoo Kim, Jong-eun Lee, Sol Choy
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Abstract
Disclosed are attenuated Salmonella gallinarum expressing FliC (flagellin) or FliC-hIL2 (human IL2 fused to FliC) and use thereof, wherein the Salmonella strain exhibits excellent immune activation ability and anticancer efficacy and thus can be used as a cancer therapeutic agent, together with or independently from existing anticancer agents.
Claims1
A method for treating, preventing, alleviating, or inhibiting cancer, comprising administering to a subject in need thereof a pharmaceutical composition comprising as an active ingredient,
- a Salmonella gallinarum strain into which a vector containing a polynucleotide encoding IL-2 (interleukin-2) fused with FliC (a filament structural protein) is introduced,
- wherein the polynucleotide encoding IL-2 fused with FliC includes the sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.