Sulfated C19 steroid hormones to treat and/or prevent proteotoxicity in protein-aggregation diseases
AssigneeUniversidad Pablo De Olavide
InventorsManuel J. Muñoz, Mercedes M. Pérez-Jiménez, Ángel M. Carrión
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Abstract
The present invention is encompassed within the field of medicine and provides a composition for use in the treatments and/or prevention of protein-aggregation diseases.
Claims14
A method for the treatment of proteotoxicity in a protein-aggregation disease in a subject, wherein the protein-aggregation disease is Alzheimer's disease or Parkinson's disease, comprising administering a composition comprising sulfated C19 androgens selected from the group consisting of testosterone sulfate (TS), or any salts or esters thereof, and epitestosterone sulfate (ES), or any salts or esters thereof, to the subject.
A method for slowing down the progression of a protein-aggregation disease by inhibiting the formation of protein aggregates and/or delaying the onset of the protein-aggregation disease by inhibiting the formation of protein aggregates, wherein the protein-aggregation disease is Alzheimer's disease, or Parkinson's disease, comprising administering a composition comprising sulfated C19 androgens selected from the group consisting of testosterone sulfate (TS), or any salts or esters thereof, and epitestosterone sulfate (ES), or any salts or esters thereof, to the subject.
Dependencies are inferred from the claim text.