Abuse-resistant pharmaceutical composition for the treatment of opioid dependence
AssigneeEdenbridge Pharmaceuticals, LLC
InventorAndreas Fischer
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Abstract
There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in associative admixture with particles comprising a weak acid, or particles comprising weakly-acidic buffer forming materials. The composition may further comprise a disintegrant and/or particles of a pharmacologically-effective amount of naloxone, or a pharmaceutically-acceptable salt thereof. The compositions are useful in the treatment of opioid dependency/addiction and/or pain.
Claims10
A process for making a tablet comprising buprenorphine or pharmaceutically-acceptable salt thereof and naloxone or a pharmaceutically-acceptable salt thereof, which process comprises:
- (a) associatively admixing microparticles of said buprenorphine or pharmaceutically-acceptable salt thereof with particles of citric acid by a process of simple mixing and/or dry granulation, to form an associative admixture between the microparticles of buprenorphine or salt thereof and the particles of citric acid;
- (b) mixing the associative admixture obtained in step (a) with a disintegrant and particles comprising said naloxone or pharmaceutically-acceptable salt thereof;
- and
- (c) compressing the mixture obtained in step (b) to produce said tablet.
Dependencies are inferred from the claim text.