ALA and salt formulation
AssigneeMolecular Product Management, LLC
InventorWilliam C. Zolentroff
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Abstract
The addition of a salt to an ALA formulation that is dissolved in the mouth unexpectedly significantly reduces the degree of burning or irritation from ALA exposure during administration. This invention is particularly useful for an oral dissolved form of administration due to the extended time of ALA exposure that is possible with such formulations. The salt-inclusive formulations of the invention can increase efficacy of the ALA administration, reduce negative side effects, or both.
Claims25
An orally dissolvable tablet comprising (a) alpha-lipoic acid in a weight concentration of 12%-45% and (b) a physiologically acceptable salt wherein the weight concentration ratio of the salt to the alpha-lipoic acid in the tablet is in the range between 5% and 200%, wherein the tablet is non-chewable and adapted to be maintained in a recipient's mouth until fully dissolved within 10 minutes following administration.
An orally administered and orally dissolving formulation comprising alpha-lipoic acid and a salt comprising a cation and an anion, wherein the formulation is non-chewable and is adapted to be maintained in a recipient's mouth until fully dissolved within 10 minutes following administration.
An orally administered and orally dissolving formulation comprising alpha-lipoic acid and a salt comprising a cation and an anion, wherein the formulation is non-chewable and is adapted to be dissolved within 10 minutes following administration when maintained in a recipient's mouth.
Dependencies are inferred from the claim text.