Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof

A method of rapidly dilating a subject's pupils, the method comprising:

• administering to the subject via intraocular injection a therapeutically effective amount of a composition consisting of:
• a therapeutically effective quantity of phenylephrine hydrochloride;
• a therapeutically effective quantity of tropicamide having a concentration in the composition of about 0.04% (w/v) to about 0.06% (w/v);
• at least one metal chelator;
• at least one anesthetic;
• optionally, at least one tonicity adjusting agent comprising one or more chloride salts selected from the group consisting of sodium chloride, potassium chloride, and magnesium chloride;
• optionally, hydrochloric acid and/or sodium hydroxide;
• at least one non-steroid anti-inflammatory drug;
• optionally, at least one excipient;
• and
• a quantity of sterile water,
• wherein the subject's pupils are dilated from a first diameter to a second diameter within one minute or less after administering the composition, wherein the difference between the first diameter and the second diameter is from about 5.0 mm to about 7.0 mm.