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US 12,702,346 B2Granted
Systems and methods for vagus nerve monitoring and stimulation
AssigneeAlfred E. Mann Foundation for Scientific Research
InventorsBrian V. Mech, Neil Talbot, Brian M. Shelton, Joseph L. Calderon, Robert J. Greenberg
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Abstract
The present disclosure generally relates to devices, systems, and methods for detecting, monitoring, predicting, and/or treating medical conditions (e.g., epileptic seizures) using one or more sensors configured to collect biomarker data from a human subject (e.g., vagal tone and/or physiological or other biomarkers).
Claims31
A monitoring system, comprising:
- one or more sensors, comprising an electroencephalogram (“EEG”) sensor;
- a heart rate sensor;
- and/or an electromyography (“EMG”) sensor, wherein the one or more sensors is configured to detect, measure, and/or monitor one or more biomarkers of the human subject;
- a housing, configured to be worn on a head of the human subject;
- a light sensor, integrated into the housing and configured to detect a signal indicative of an ambient light level;
- at least one pupillometer, integrated into the housing and configured to detect a signal indicative of a pupil size of the human subject;
- and
- a controller, comprising a processor and memory, communicatively linked to the one or more sensors, the light sensor, and the at least one pupillometer, wherein the controller is configured to
- (a) determine an ambient light level based on the signal detected by the light sensor;
- (b) determine a pupil size of the human subject, based on the signal detected by the pupillometer;
- (c) determine a normalized pupil size measurement for the human subject, based on the ambient light level and the pupil size of the human subject;
- and
- (d) predict a likelihood of the human subject experiencing a seizure within a predetermined time period, and a classification of the seizure, using one or more pre-trained classifiers, based on (i) the one or more biomarkers detected, measured, and/or monitored by the one or more sensors, and (ii) the normalized pupil size measurement.
10 more elements
A method of monitoring seizures experienced by a human subject, comprising:
- obtaining a first set of biomarkers for the human subject using one or more sensors, comprising an electroencephalogram (“EEG”) sensor, a heart rate sensor;
- and/or an electromyography (“EMG”) sensor, wherein the one or more sensors is configured to detect, measure, and/or monitor one or more biomarkers of the human subject;
- and
- detecting a signal indicative of an ambient light level, from a light sensor integrated into a housing worn on the head of the humans subject;
- detecting a signal indicative of a pupil size of the human subject, using at least one pupillometer integrated into the housing worn on the head of the humans subject;
- determining an ambient light level based on the signal detected by the light sensor, and a pupil size of the human subject, based on the signal detected by the pupillometer;
- determining a normalized pupil size measurement for the human subject, based on the ambient light level and the pupil size of the human subject;
- and
- predicting a likelihood of the human subject experiencing a seizure within a predetermined time period, and a classification of the seizure, using one or more pre-trained classifiers, based on (i) the one or more biomarkers detected, measured, and/or monitored by the one or more sensors, and (ii) the normalized pupil size measurement.
6 more elements
Dependencies are inferred from the claim text.