Intraoperative probe for cancer diagnosis and treatment
Assignee123IV, Inc.
InventorAllen B. Chefitz
Life of this patent
Estimating the term…
Abstract
An intraoperative probe combines Raman spectroscopy, shear wave elastography (SWE), and photodynamic therapy (PDT), preferably in a single hand-held device with real-time machine learning analysis. The machine learning independently analyzes and then fuses the data from different modalities for real-time cancer diagnostic predictions. The approach herein leverages simultaneous (or near-simultaneous) collection and real-time processing of Raman and SWE data for immediate cancer diagnostic feedback and therapeutic action. The hand-held device is precisely configured to target the same focal point with three different modalities—Raman, SWE, and PDT—by positioning the modalities within the device into the same location, either with an array of mirrors or an automatic or manual rotation mechanism.
Claims22
An intraoperative surgical probe for detecting and treating cancerous tissue in real-time, comprising:
- a housing;
- a motion tracking unit that receives one or more inputs, and in response continually generates tracking data representing a displacement of a focal region of tissue, and a predicted motion of the focal region over a given time horizon;
- a first detection unit controllable to output a first output beam along a first axis, and in response receive first data;
- a second detection unit controllable to output a second output beam along a second axis, and in response receive second data;
- a treatment unit controllable to output a third output beam along a third axis
- wherein the first, second and third axes are co-aligned so as to selectively converge one or more of the first, second and third output beams on the focal region of tissue;
- and
- a control unit having a first portion, a second portion, and a third portion;
- the first portion receiving and processing the tracking data to generate one or more output signals indicating that a residual motion of the focal region is less than a threshold;
- the second portion responsive to a first output signal to activate the second detection unit in association with the first detection unit, to receive and analyze the first and the second data, generate respective first and second diagnostic outputs, and based on the first and second diagnostic outputs classify the tissue as normal or diseased;
- and
- the third portion responsive to an indication from the second portion that the tissue is diseased together with receipt of a second output signal to arm the treatment unit to output the third output beam on the focal region of tissue.
Dependencies are inferred from the claim text.