System and method for assessment of neuro-inflammation using magnetic resonance imaging (MRI)
AssigneeWisconsin Alumni Research Foundation
InventorJohn-Paul Jaewoon Yu
Life of this patent
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Abstract
A system and method are provided for non-invasively assessing neuro-inflammation in a subject. The method includes acquiring neurite orientation dispersion and density imaging (NODDI) data of the subject and processing the NODDI data to determine an orientation dispersion index (ODI) component of the NODDI data. The method also includes assessing the ODI component against one of a reference of neuro-inflammation or a prior ODI component acquired from the subject to determine one of an acute assessment or a chronic assessment of neuro-inflammation in the subject. The method further includes generating a report indicating the one of an acute assessment or a chronic assessment of neuro-inflammation in the subject.
Claims20
A method for non-invasively assessing neuro-inflammation in a subject comprising:
- acquiring, using a computer system, neurite orientation dispersion and density imaging (NODDI) data of the subject;
- processing, using the computer system, the NODDI data to determine an orientation dispersion index (ODI) component of the NODDI data;
- assessing, using the computer system, the ODI component against one of a reference of neuro-inflammation or a prior ODI component acquired from the subject to distinguish an acute neuro-inflammation in the subject from chronic neuro-inflammation in the subject and quantify the acute neuro-inflammation or the chronic neuro-inflammation;
- and
- generating, using the computer system, a report indicating the quantified acute neuro-inflammation or the quantified chronic neuro-inflammation in the subject.
A method for non-invasively assessing neuro-inflammation in a subject, the method comprising:
- acquiring neurite orientation dispersion and density imaging (NODDI) data of the subject;
- processing the NODDI data to determine an orientation dispersion index (ODI) component of the NODDI data;
- assessing the ODI component against one of a reference of neuro-inflammation or a prior ODI component acquired from the subject to determine an acute neuro-inflammation and chronic neuro-inflammation in the subject;
- and
- generating a report indicating the acute neuro-inflammation and the chronic neuro-inflammation in the subject.
Dependencies are inferred from the claim text.