Open port probe interfaces

A device for introducing a sample to a mass spectrometer, comprising:

• a chamber extending from a top end to a bottom end, the top end of the chamber configured to be releasably and replaceably coupled to an adapter receiving a sample holder;
• a sampling probe with an open end disposed in the chamber and defining a sampling space to receive one or more sample analytes through an adapter channel defined in the adapter, wherein the sampling probe includes an outlet port configured to be in fluid communication with an ionization source to deliver the one or more sample analytes thereto;
• and
• a solvent inlet port coupled to the chamber to receive a solvent and direct the solvent to the sampling space of the sampling probe;
• wherein the top end of the chamber comprises an external mounting surface to which the adapter releasably and replaceably couples, and wherein the adapter comprises a top surface and a side wall extending downwardly from the top surface, with the side wall including an inner surface configured to engage the external mounting surface of the top end of the chamber upon coupling of the adapter to the chamber.

A kit for use with a mass spectrometer comprising:

• an interfacing device for introducing a sample to a mass spectrometer, the interfacing device comprising:
• a chamber extending from a top end to a bottom end;
• a sampling probe with an open end disposed in the chamber and defining a sampling space to receive one or more sample analytes;
• and
• a solvent inlet port coupled to the chamber to receive a solvent and direct the solvent to the sampling space of the sampling probe;
• two or more adapters, each configured to releasably and replaceably couple to the chamber to align a sample holder with the open end of the probe, wherein the adapter receives the sample holder and delivers sample analytes from the sample holder to the open end of the sampling probe through an adapter channel defined in the adapter;
• and
• two or more different sample holders;
• wherein the chamber is configured to releasably and replaceably couple at its top end to each of the two or more adapters separately, each of the two or more adapters being configured to align a respective one of the two or more different sample holders with the sampling space of the sampling probe when the sampling probe is coupled to the adapter;
• wherein the top end of the chamber comprises an external mounting surface to which each of the two or more adapters releasably and replaceably couples, and wherein each of the two or more adapters comprises a top surface and a side wall extending downwardly from the top surface, with the side wall including an inner surface configured to engage the external mounting surface of the top end of the chamber upon coupling of the each of the two or more adapters to the chamber.