US 12,700,519 B2 · Method for manufacturing and increasing the yield of a medical strontium-82/rubidium-82 generator

Abstract

Disclosed is a method for preparing a strontium-82/rubidium-82 generator. The method includes: filling a column volume with a sorbent made of hydrated tin (IV) oxide; passing through the column an initial solution with strontium-82 radionuclide, which also contains ions of stable isotopes of calcium and strontium; and washing out rubidium-82 with a saline solution of 0.9% sodium chloride. In order to achieve a breakthrough of strontium-82 or strontium-85 below permissible levels, 0.01 and 0.1 kBq per 1 MBq 82Rb, respectively, when passing not less than 17 liters of saline solution through columns with a volume of not less than 1.6 cm3 and a dry sorbent weight of not less than 3.8 g, a specific activity of strontium-82 in the initial solution is not less than 90 GBq (2400 mCi) per mg of stable strontium cations for a generator with an activity of 3700 MBq (100 mCi).

Claims6

Dependent claims

A process for preparing a strontium-82/rubidium-82 generator, comprising the steps of:

filling a column volume with a sorbent made of hydrated tin (IV) oxide, passing through the column an initial solution with strontium-82 radionuclide, which also contains ions of stable isotopes of calcium and strontium, washing out rubidium-82 with a saline solution of 0.9% sodium chloride, wherein to achieve a breakthrough of strontium-82 or strontium-85 below permissible levels (0.01 and 0.1 kBq per 1 MBq 82Rb, respectively) when passing not less than 17 liters of saline solution through columns with a volume of not less than 1.6 cm3 and a dry sorbent weight of not less than 3.8 g, a specific activity of strontium-82 in the initial solution is not less than 90 GBq (2400 mCi) per mg of stable strontium cations for a generator with an activity of 3700 MBq (100 mCi).

A process for preparing a strontium-82/rubidium-82 generator, comprising the steps of:

filling a column volume with a sorbent of hydrated tin (IV) oxide,
passing through the column an initial solution with strontium-82 radionuclide, which also contains ions of stable isotopes of calcium and strontium, and washing out rubidium-82 with a saline solution of 0.9% sodium chloride, wherein to achieve a breakthrough of strontium-82 or strontium-85 below permissible levels (0.01 and 0.1 kBq 1 MBq 82Rb, respectively) when passing not less than 17 liters of saline solution, a content of stable isotopes of strontium and calcium in a solution containing strontium-82 radionuclide passed through the column during loading the generator is chosen such that it (1 μmol of strontium cations+0.11 μmol of calcium cations) does not exceed 0.67 μmol per 1 g of dry sorbent in columns with a volume of 1.6 cm3 to 3.0 cm3 and a dry sorbent weight of 3.8 g to 7.2 g of dry sorbent.

Dependencies are inferred from the claim text.

Method for manufacturing and increasing the yield of a medical strontium-82/rubidium-82 generator

Life of this patent

Method for manufacturing and increasing the yield of a medical strontium-82/rubidium-82 generator

Life of this patent

Abstract

Claims6