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US 12,699,104 B2Granted
Heart failure marker
AssigneesNational University Corporation Kagawa University, Shionogi & Co., Ltd.
InventorsTetsuo Minamino, Shota Yokoyama, Ryo Kawakami
Life of this patent
Estimating the term…
Abstract
A method for measuring heart failure risk, including: (A) measuring an angiotensinogen amount value of urine collected from a subject; and (B) comparing an angiotensinogen amount value of urine previously collected from the subject with the angiotensinogen amount value measured in (A).
Claims9
A method of treating or preventing heart failure in a subject identified as having an increased urinary angiotensinogen amount value, the method comprising:
- administering a heart failure drug to the subject identified as having an increased urinary angiotensinogen amount value for treating or preventing heart failure,
- wherein the urinary angiotensinogen amount value is a value obtained by measuring an angiotensinogen amount and a creatinine amount in a urine sample collected from the subject at a defined time and dividing urinary angiotensinogen mass by urinary creatinine mass, and the value is converted into “urinary angiotensinogen mass (μg)/urinary creatinine mass (g)”, and
- wherein the subject is identified as having an increased urinary angiotensinogen amount value when the measured urinary angiotensinogen amount value is 1.2 times or more than the value measured in a urine sample collected from the subject prior to the defined time.
Dependencies are inferred from the claim text.