Biological markers in the diagnosis of endometriosis
AssigneeYeditepe Universitesi
InventorsInci Kurt Celep, Dilek Telci Temeltas, Fikrettin Sahin, Melike Batukan, Halime Siginc
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Abstract
Combinations of the novel biological markers that can be used in the diagnosis of endometriosis are provided. The objective of the invention is to detect biological markers that are expressed differently in eMSCs isolated from endometrial biopsy samples in the diagnosis of endometriosis compared to healthy eMSCs. A tissue transglutaminase is configured as a biomarker for a diagnosis of an endometriosis in isolated endometrial mesenchymal stem cells derived from an endometrial biopsy and/or a menstrual blood from endometriosis patients.
Claims10
A diagnostic kit for detecting endometriosis in a human subject, comprising:
- (a) at least one reagent for detecting tissue transglutaminase (tTG) mRNA expression, tTG protein expression, or both;
- and
- (b) at least one reagent for detecting at least one biomarker selected from the group consisting of cluster of differentiation 146 (CD146), sushi domain containing protein 2 (SUSD2), integrin beta 1 (ITGB1), and platelet derived growth factor receptor (PDGFR);
- wherein the diagnostic kit is configured to measure an expression level of the tTG and the at least one biomarker in mesenchymal stem cells isolated from eutopic endometrial tissue and/or menstrual blood.
Dependencies are inferred from the claim text.