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AssigneeThe Research Foundation for The State University of New York
InventorsAudrey Bernstein, Alexey Wolfson, Sean McCauley
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The present disclosure provides compositions and methods for using self-deliverable siRNA (sdRNAi) directed against USP-10 for the treatment of various medical conditions, including skin scaring due to trauma wounds and surgery, corneal and retina scaring due to injury and surgery, internal organ scaring due to injury and surgery, heart tissue scaring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. In embodiments, compositions including self-deliverable siRNA (sdRNAi) directed against USP-10 are suitable for use in pharmaceutical formulations and treatments resulting in significant less scar formation, and include synthetic nucleic acids such as sense and antisense oligonucleotides.
A composition comprising a synthetic nucleic acid comprising a polynucleotide sequence of one of SEQ ID NOs:
A composition comprising a synthetic nucleic acid comprising a polynucleotide sequence of one of SEQ ID NOs:
A composition comprising a double-stranded self-deliverable siRNA (sdRNAi) comprising a first synthetic nucleic acid and a second synthetic nucleic acid, wherein:
A composition comprising a double-stranded self-deliverable SiRNA (sdRNAi) comprising a first synthetic nucleic acid and a second synthetic nucleic acid, wherein:
Dependencies are inferred from the claim text.