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US 12,698,500 B2Granted
CTGF gene-specific double-stranded oligonucleotide, and a composition for preventing and treating fibrotic diseases and respiratory-related diseases comprising same
AssigneeBioneer Corporation
InventorsHan-Oh Park, Tae-Rim Kim, Young-Ho Ko, Sung Il Yun, Jun Hong Park
Life of this patent
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Abstract
The present invention relates to a double-stranded oligonucleotide capable of inhibiting CTGF expression with a very specific and high efficiency, a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, and a use thereof in preventing or treating of fibrotic or respiratory diseases.
Claims16
A connective growth tissue factor (CTGF)-specific double-stranded oligonucleotide construct for inducing RNAi via siRNA or shRNA, having a structure of Structural Formula (1) below:
- A-X—R—Y—B Structural Formula (1)
- wherein in Structural Formula 1, A is a hydrophilic material, B is a hydrophobic material, X and Y are each independently a simple covalent bond or a linker-mediated covalent bond, and R is a double-stranded oligonucleotide for inducing RNAi via siRNA or shRNA, said double-stranded oligonucleotide comprising a sense strand consisting of the sequence of SEQ ID NO:
- 10 and an antisense strand comprising a sequence complementary thereto, wherein the sense strand is DNA, and the antisense strand is RNA.
Dependencies are inferred from the claim text.