Caspase-2 variants
AssigneeBoehringer Ingelheim International GmbH
InventorsAlois Jungbauer, Nico Lingg, Gerald Striedner, Monika Cserjan-Puschmann, Chris Oostenbrink, Christoph Oehlknecht, Christina Kroess, Petra Engele, Rainer Schneider
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Abstract
The invention refers to a single-chain circular permuted caspase-2 comprising the following structure from N- to C-terminus: i) a small subunit of a caspase-2, or a functionally active variant thereof; and ii) a large subunit of a caspase-2, or a functionally active variant thereof, wherein the cp caspase-2 comprises one or more amino acid substitutions increasing P1′ tolerance of the cp caspase-2 compared to a cp caspase-2 without the amino acid substitutions.
Claims13
A single-chain circular permuted caspase-2 (cp caspase-2) comprising the following structure from N- to C-terminus:
- i. a small subunit of a caspase-2;
- and
- ii. a large subunit of a caspase-2,
- wherein said cp caspase-2 comprises an amino acid sequence having at least 90% sequence identity to SEQ ID NO:
- 6, and
- wherein said cp caspase-2 comprises one or more amino acid substitutions increasing P1′ tolerance of said cp caspase-2 compared to a cp caspase-2 without said amino acid substitutions.
Dependencies are inferred from the claim text.