Live attenuated strain of Streptococcus pneumoniae and pharmaceutical compositions comprising a live attenuated strain of S. pneumoniae
AssigneeUCL Business PLC
InventorsJeremy Brown, Elisa Ramos-Sevillano
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Abstract
A live attenuated strain of S. pneumoniae containing at least two genes or operons that have disrupted expression or encode for proteins that have impaired function, the two genes or operons being fhs, piaA, proABC, spxB, Sp_1288 and Sp_1027. Pharmaceutical compositions containing the live attenuated strains are also described. The live attenuated strains and pharmaceutical compositions can be used to boost immunity in a subject and prevent S. pneumoniae infection.
Claims24
A live attenuated strain of Streptococcus pneumoniae, the live attenuated strain comprising at least two genes or operons that have disrupted expression or encode for a protein with impaired function, wherein the at least two genes or operons are selected from fhs, piaA, proABC, spxB, Sp_1288, and Sp_1027.
A method of ameliorating infection and/or enhancing immunity in a subject, comprising:
- administering to a subject in need thereof a therapeutically effective amount of a live attenuated strain of Streptococcus pneumoniae or a pharmaceutical composition of the live attenuated strain of Streptococcus pneumoniae;
- wherein the live attenuated strain of Streptococcus pneumoniae comprises at least two genes or operons that have disrupted expression or encode for a protein with impaired function and wherein the at least two genes or operons are selected from fhs, piaA, proABC, spxB, Sp_1288, and Sp_1027.
Dependencies are inferred from the claim text.