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US 12,698,346 B2Granted
Parathyroid hormone receptor 1(PTH1R) antibodies and uses thereof
AssigneeXoma (US) LLC
InventorsRaphael D. Levy, Hassan Issafras, Agnes Choppin Holmes, Kirk W. Johnson, Amer M. Mirza, Daniel H. Bedinger, Rachel A. Hunt, Toshihiko Takeuchi, Kiranjit Kaur Ahluwalia, Robyn Cotter
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Abstract
The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.
Claims11
An antibody that binds parathyroid hormone receptor 1 (PTH1R) with an affinity Kd of 2×10−8 M or less, wherein the antibody comprises:
- (a) a heavy chain CDR1 amino acid sequence set forth in SQ ID No:
- 45;
- (b) a heavy chain CDR2 amino acid sequence set forth in SQ ID No:
- 46;
- (c) a heavy chain CDR3 amino acid sequence set forth in SQ ID No:
- 47;
- (d) a light chain CDR1 amino acid sequence set forth in SQ ID No:
- 149;
- (e) a light chain CDR2 amino acid sequence set forth in SQ ID No:
- 150;
- and
- (f) a light chain CDR3 amino acid sequence set forth in SQ ID No:
- 151;
- wherein the antibody is an IgG1 antibody.
11 more elements
Dependencies are inferred from the claim text.