Anti-IDE antibodies and uses of same
AssigneeRamot at Tel-Aviv University Ltd.
InventorsItai Benhar, Limor Nahary, Dan Frenkel, Ofir Fursht, Yuval Nash, Mirit Liran
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Abstract
Isolated anti-IDE antibodies are provided. Each of the antibodies comprise an antigen recognition domain comprising the indicated CDR amino acid sequences. Methods of producing same, methods of using same, pharmaceutical compositions comprising same and articles of manufacture are also provided.
Claims11
An isolated antibody comprising an antigen recognition region, which specifically binds insulin-degrading enzyme (IDE), wherein said antigen recognition domain comprises complementarity determining region (CDR) amino acid sequences as set forth in
- SEQ ID NOs:
- 36 (CDR1), 38 (CDR2) and 40 (CDR3), being sequentially arranged from N to C on a heavy chain of said antibody;
- and 44 (CDR1), 46 (CDR2) and 48 (CDR3), being sequentially arranged from N to C on a light chain of said antibody.
An isolated polynucleotide comprising a nucleic acid sequence encoding an antibody comprising an antigen recognition region, which specifically binds insulin-degrading enzyme (IDE), wherein said antigen recognition domain comprises complementarity determining region (CDR) amino acid sequences as set forth in SEQ ID NOs:
- 36 (CDR1), 38 (CDR2) and 40 (CDR3), being sequentially arranged from N to C on a heavy chain of said antibody;
- and 44 (CDR1), 46 (CDR2) and 48 (CDR3), being sequentially arranged from N to C on a light chain of said antibody.
A host cell expressing an antibody comprising an antigen recognition region, which specifically binds insulin-degrading enzyme (IDE), wherein said antigen recognition domain comprises complementarity determining region (CDR) amino acid sequences as set forth in SEQ ID NOs:
- 36 (CDR1), 38 (CDR2) and 40 (CDR3), being sequentially arranged from N to C on a heavy chain of said antibody;
- and 44 (CDR1), 46 (CDR2) and 48 (CDR3), being sequentially arranged from N to C on a light chain of said antibody.
Dependencies are inferred from the claim text.