CAR-CD123 vector and uses thereof
AssigneeOspedale Pediatrico Bambino Gesu'
InventorsConcetta Quintarelli, Biagio De Angelis, Franco Locatelli
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Abstract
The present invention relates to a chimeric antigen receptor (CAR) molecule containing, from the N-terminus to the C-terminus: a) an extracellular domain and transmembrane domain of human CD19, b) an antigen binding domain, c) a spacer domain, d) a transmembrane domain, and e) a cytoplasmatic domain, preferably wherein the CAR is a CD123 specific CAR (CD123 CAR) and the antigen binding domain includes a VL and/or VH from a monoclonal anti-CD123 antibody, more preferably the antigen binding domain includes a single chain variable fragment (scFv) that specifically binds to CD123.
Claims7
A chimeric antigen receptor (CAR) molecule comprising, the sequence of SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.