Biological binding molecules
OwnerHolger Klapproth, Marc A. Kessemeier +1inventors
InventorsHolger Klapproth, Marc A. Kessemeier, Ulrich Birsner
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Abstract
The invention relates to the field of the preparation, identification and selection of biological binding molecules such as antibodies or fragments thereof, and also the use thereof in the context of therapy and prophylaxis of cancers, such as malignant B-cell neoplasia in particular. The binding molecules are capable of selectively binding to B-cell receptors that have a light chain according to SEQ ID NO. 18.
Claims9
A biological binding molecule which selectively binds to B cell receptors, characterized by the presence of a light chain having a sequence according to SEQ ID No. 18, but not to B-cell receptors lacking a light chain according to SEQ ID No. 18, wherein the biological binding molecule is an antibody or a functional fragment thereof having an antigen-binding site, and wherein the biological binding molecule comprises variable parts of a heavy chain corresponding to CDR1, CDR2 and CDR3 given respectively in SEQ ID NO(s). 19, 20 and 21 and variable parts of a light chain corresponding to CDR1, CDR2 and CDR3 given respectively in SEQ ID NO(s). 22, 23 and 24.
Dependencies are inferred from the claim text.