Peptides for beta-cell survival and insulin production
AssigneesProtean Bio, Inc., The University of New South Wales
InventorsKerry-Anne Rye, Madhav Devalaraja, Maté Biro, Blake Cochran, Thomas King, Szun Tay, Feyza Colakoglu, Vanesaa Prajitno
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Abstract
A method to prevent a disease, comprising: (1) administering a peptide comprising Delta6PV into a subject comprising a human or an animal; wherein the disease comprises one of more of Type 1 diabetes, rheumatoid arthritis, lupus, Sjogren's syndrome, multiple sclerosis, Graves' disease, giant cell arteritis, ankylosing spondylitis, and Guillain Barre Syndrome; and (2) monitoring the disease in the subject.
Claims19
A method to delay onset of a disease, comprising:
- taking a composition comprising Delta6PV, and administering an effective amount of the composition into a subject, wherein the disease comprises type 1 diabetes, wherein the subject is a human or an animal, wherein the Delta6PV in the subject:
- (a) delays onset of infiltration of immune cells into islets;
- (b) does not impair T cell cytotoxicity;
- and
- (c) inhibits IL-2 driven expansion of primary T cells.
A method to treat a disease, comprising:
- taking a composition comprising Delta6PV, and administering an effective amount of the composition into a subject, wherein the disease comprises type 1 diabetes, wherein the Delta6PV in the subject inhibits IL-2 driven expansion of primary human T cells, and wherein the subject is a human or an animal.
Dependencies are inferred from the claim text.