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US 12,698,306 B2Granted
Bile acid-GCPII inhibitor conjugates to treat inflammatory diseases, including inflammatory bowel disease (IBD)
AssigneesThe Johns Hopkins University, Institute of Organic Chemistry and Biochemistry of the AS CR, V.V.I.
InventorsBarbara Slusher, Diane E. Peters, Rana Rais, Pavel Majer, Lukas Tenora, Ivan Snajdr
Life of this patent
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Abstract
GCPII inhibitors comprising 2-(phosphonomethyl) pentanedioic acid (2-PMPA) conjugated to a bile acid and their use for treating a disease or condition associated with elevated levels of GCPII, including inflammatory bowel disease.
Claims6
A compound selected from the group consisting of:
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.