Process for preparing 3-amino-1-butanol and related compounds

Abstract

Disclosed herein are methods and processes of preparing 3-amino-(C3-6)-alkan-1-ol, including optically active 3-amino-(C3-6)-alkan-1-ol (e.g., optically active 3-amino-1-butanol such as (R)-3-amino-1-butanol). The 3-amino-(C3-6)-alkan-1-ol may be optionally substituted at the 1-position, e.g., with OH, alkoxy, O-acetyl, or silyl groups, among others. The processes include contacting a 1-nitro-(C1-4)-alkane with a vinyl source or an acetylene source in the presence of a base and a dehydrating agent to provide 3-(C0-3)-alkyl-2-isoxazoline; and/or contacting the 3-(C0-3)-alkyl-2-isoxazoline with hydrogen and a hydrogenation catalyst to provide 3-amino-(C3-6)-alkan-1-ol.

Dependencies are inferred from the claim text.