Transcriptional enhanced associate domain (TEAD) transcription factor inhibitors and uses thereof

A compound of Formula (I-e):

• or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, stereoisomer or isotopically labeled derivative thereof wherein:
• R1 is hydrogen, trifluoromethyl, or N(Ra)(Rb), wherein Ra is optionally substituted alky;
• Rb is optionally substituted alkyl, or Ra and Rb together with the nitrogen atom to which they are attached form a heterocycle;
• R2 is hydrogen, halogen, optionally substituted acyl, optionally substituted alkyl, haloalkyl, optionally substituted heteroalkyl, trifluoromethyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —ORc, —NO2, —N(Rc)2, or —SRc, wherein Rc is independently selected from hydrogen, optionally substituted acyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, and a sulfur protecting group when attached to a sulfur atom, or optionally, R2 can be joined together with X1 to form an optionally substituted heterocyclic ring;
• A is an optionally substituted heterocyclic ring, such that:
• i) Ring A is an optionally substituted heterocyclic ring wherein each heteroatom is selected from nitrogen and sulfur when X1 is a bond, and ii) Ring A is not indolinyl when X1 is —O—;
• V1 is —C(R2)—;
• X1 is a bond or O, S, —CH2N(Rd)—, or —N(Rd)—, wherein Rd is a bond, hydrogen, substituted or unsubstituted C1-6 alkyl, or a nitrogen protecting group, or optionally Rd can be joined together with one instance of R2 to form an optionally substituted heterocyclic ring;
• X2 is a bond;
• m is 0, 1, 2, 3 or 4;
• D1 is
• wherein:
• L3 is a bond or an optionally substituted C1-4 hydrocarbon chain, optionally wherein one or more carbon units of the hydrocarbon chain are independently replaced with —NRL3a—, wherein RL3a is hydrogen;
• RE1 is hydrogen;
• RE2 is selected from the group consisting of hydrogen and —CH2N(RE2a)2, wherein each occurrence of RE2a is independently selected from the group consisting of alkyl;
• and
• RE3 is hydrogen;
• Y is O.