Method for performing Mitsunobu reaction between alcoholic hydroxyl group donor and active hydrogen donor

A method for performing Mitsunobu reaction between an alcoholic hydroxyl group donor and an active hydrogen donor, which specifically comprises the following steps:

• performing reaction of the alcoholic hydroxyl group donor, the active hydrogen donor, a trihydrocarbylphosphine reagent and an azodicarboxylate reagent in the presence of an organic solvent to obtain the product of dehydration condensation of the alcoholic hydroxyl group donor and the active hydrogen donor;
• wherein, the organic solvent is a C8-16 linear or branched alkane;
• wherein the alcoholic hydroxyl group donor is selected from the group consisting of 4′-propyl-[1,1′-bis(cyclohexane)]-4-yl)methanol, 4-(4-ethyl-2-fluorophenyl)cyclohexanol, 4-(2′,3′-difluoro-4′-methyl-[1,1′-biphenyl]-4-yl)cyclohexanol, and 4-(3-fluoro-4-isopropylphenyl)cyclohexanol;
• and
• wherein the active hydrogen donor is selected from the group consisting of 4-ethoxy-2,3-difluorophenol, 4-(4-propylcyclohexyl)aniline, and 4-propylbenzoic acid.