Hyper efficient separations device
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsMark Hayes, Claire Crowther, Paul Jones
Life of this patent
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Abstract
The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.
Claims10
A multi-length scale structure for use in an insulator-based dielectrophoresis device for separating at least one analyte from a fluid, the device including a fluid flow channel disposed on a substrate, the fluid flow channel being defined by a first wall, and a second wall spaced from the first wall, the multi-length scale structure comprising:
- an insulating flow structure extending from the first wall toward the second wall thereby defining a constriction in the fluid flow channel between the first wall and the second wall, the insulating flow structure comprising a base section and a plurality of projections extending from the base section toward the second wall,
- wherein the plurality of projections are elliptically shaped,
- wherein a base height of the base section is greater than a projection height of each of the plurality of projections,
- wherein the projection height is in a range of 50 nm to 50 μm, and
- wherein the plurality of projections are structured to create uniform projection heights at a plateau of greatest constriction of the insulating flow structure, and
- wherein the base section is elliptically shaped.
A multi-length scale structure for use in an insulator-based dielectrophoresis device for separating at least one analyte from a fluid, the device including a fluid flow channel disposed on a substrate, the fluid flow channel being defined by a first wall, and a second wall spaced from the first wall, the multi-length scale structure comprising:
- an insulating flow structure extending from the first wall toward the second wall thereby defining a constriction in the fluid flow channel between the first wall and the second wall, the insulating flow structure comprising a base section and a plurality of projections extending from the base section toward the second wall,
- wherein the plurality of projections are elliptically shaped,
- wherein a base height of the base section is greater than a projection height of each of the plurality of projections,
- wherein the projection height is in a range of 50 nm to 50 μm, and
- wherein the plurality of projections are structured to create uniform projection heights at a plateau of greatest constriction of the insulating flow structure,
- wherein the second wall includes a second insulating flow structure extending toward the first wall thereby further defining the constriction in the fluid flow channel between the first wall and the second wall, the second insulating flow structure comprising a second base section and a second plurality of projections extending from the second base section toward the first wall, and
- wherein the second base section is elliptically shaped and the second plurality of projections are elliptically shaped.
Dependencies are inferred from the claim text.