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US 12,697,566 B2Granted
Parallel chromatography systems and methods
AssigneeAmgen Inc.
InventorsJeremy S. Conner, Glenn M. Hunter, Kenneth Shoemaker, Neil Soice, Bret Wylie, John B. Flynn, Nakorn Kaeonil, Thuy N. Nguyen, Siddharth Singh
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Abstract
Parallel chromatography systems and continuous manufacturing methods are described herein that utilize two or more chromatography column skids having columns operating in parallel with automation controls governing which column to load at a given time.
Claims20
A continuous parallel chromatography system, the system comprising:
- a plurality of chromatography column skids having no flow path between or connecting the plurality of chromatography column skids to one another, each chromatography column skid suitable for independent batch processing and comprising:
- a chromatography column;
- an inlet selectively coupled to an upstream source;
- at least one pump;
- at least one filter;
- and
- an outlet sensor;
- a control circuit configured to control the operation of the plurality of chromatography column skids through one or more full cycles of a chromatography process, each full cycle including a long step and a plurality of shorter steps, each of the plurality of shorter steps having a processing time shorter than or equal to a processing time of the long step, wherein the control circuit is configured to:
- receive a synchronization signal associated with a first one of the plurality of chromatography column skids that the long step is complete;
- and
- in response to reception of the synchronization signal, direct operation of a second one of the plurality of chromatography column skids to commence operation of the long step.
8 more elements
Dependencies are inferred from the claim text.