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AssigneeRealeve, LLC
InventorsPeter M. Bonutti, Justin E. Beyers
Estimating the term…
Systems, devices, and methods for modulating permeability of a membrane barrier (e.g., BBB), such as by increasing and/or decreasing porosity of the membrane barrier. The membrane barrier may be modulated indirectly through neuromodulation, which may include stimulation of an upstream neural body (e.g., a ganglion) that affects, either directly or indirectly, the permeability of the membrane barrier. Modulating a membrane barrier has uses in selective delivery of active agents or other substances through the membrane barrier into tissues or cells. In some situations, these active agents or other substances would not be able to pass through the barrier without modulation. Modulating a membrane barrier has uses in selective drainage of fluid, waste, and/or byproducts from the tissue or cells from one side of the membrane barrier, or reducing the porosity of the membrane barrier to correct a leaky barrier.
A method for controlling permeability of a blood-brain barrier in a subject, comprising:
A system for modulating blood-brain barrier permeability of a subject, comprising:
A computer-implemented method for optimizing blood-brain barrier modulation of a subject using artificial intelligence, comprising:
Dependencies are inferred from the claim text.