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US 12,697,474 B2Granted
Core-shell microneedle devices and uses thereof
AssigneeNorth Carolina State University
InventorsZhen Gu, Jinqiang Wang, Yanqi Ye
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Abstract
The present disclosure relates to microneedle devices and methods for treating a disease (for example, diabetes) using a degradable cross-linked gel for self-regulated delivery of a therapeutic agent (for example, insulin).
Claims18
A microneedle patch, comprising:
- a plurality of microneedles each having a base end and a tip;
- and
- a substrate to which the base ends of the microneedles are attached;
- wherein the microneedles comprise:
- a shell, comprising:
- a first poly (vinyl alcohol) (PVA) polymer cross-linked with a first peroxide-sensitive linker;
- and
- a peroxide scavenging enzyme encapsulated within a first nanogel, wherein the first nanogel is embedded in the first PVA polymer;
- and
- a core, comprising:
- a second poly (vinyl alcohol) (PVA) polymer cross-linked with a second peroxide-sensitive linker;
- a glucose-responsive agent encapsulated within a second nanogel, wherein the second nanogel is embedded in the second PVA polymer;
- and
- a therapeutic agent, wherein the therapeutic agent is covalently attached to the second PVA polymer with a third peroxide-sensitive linker;
- wherein the glucose-responsive agent comprises glucose oxidase;
- and
- wherein the therapeutic agent is insulin.
14 more elements
Dependencies are inferred from the claim text.