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US 12,697,420 B2Granted
Drug-eluting medical implants
AssigneeLyra Therapeutics, Inc.
InventorsMaria Palasis, Changcheng You, Danny Concagh, Lee Core, Kicherl Ho, Upma Sharma, Gregory T Zugates
Life of this patent
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Abstract
Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
Claims16
An implant, comprising:
- i) a therapeutic agent contained within one or more polymeric strands and a salt incorporated within at least one of said one or more polymeric strands;
- and
- ii) an elastomeric polymeric coating at least partially coating said one or more polymeric strands, said coating conforming to the shape of the individual strands and when compressed applies a force in favor of radial expansion.
An implant, comprising:
- i) a structure comprising one or more polymeric monofilaments and a salt;
- and
- ii) a thermoset elastomer at least partially coating said one or more polymeric monofilaments, said thermoset elastomer comprising crosslinks.
A method of delivering an implant comprising:
- a. providing;
- i) an implant comprising a therapeutic agent contained within one or more polymeric strands and a salt incorporated within at least one of said one or more polymeric strands,
- ii) an elastomeric polymeric coating at least partially coating said one or more polymeric strands, said coating conforming to the shape of the individual strands and when compressed applies a force in favor of radial expansion;
- and
- b. placing said implant in contact with a lumen of a body, such that said therapeutic agent is eluted over time.
2 more elements
A method of delivering an implant comprising:
- a. providing;
- i) an implant comprising one or more polymeric monofilaments, a therapeutic agent and a salt;
- ii) a thermoset elastomer at least partially coating said one or more polymeric monofilaments, said thermoset elastomer comprising crosslinks;
- and
- b. placing said implant in contact with a lumen of a body, such that said therapeutic agent is eluted over time.
2 more elements
An implant, comprising:
- i) a plurality of individual polymeric strands making up a framework;
- ii) a therapeutic agent contained within said polymeric strands and a salt incorporated within at least one of said one or more polymeric strands;
- and
- iii) an elastomeric polymeric coating that conforms to the shape of said individual polymeric strands and does not cover the framework of the implant.
1 more element
Dependencies are inferred from the claim text.