Bioadhesive for corneal repair
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsAli Khademhosseini, Nasim Annabi, Reza Dana, Ahmad Kheirkhah
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compositions and methods for repair and reconstruction of defects and injuries to the cornea. For example, the present disclosure provides a composition for corneal reconstruction including a methacryloyl-substituted gelatin, a visible light-activated photoinitiator, and a pharmaceutically acceptable carrier. In another example, the present disclosure provides a method for corneal reconstruction including the steps of: applying a composition and exposing the composition to visible light.
Claims18
A prepolymer solution for promoting general eye health, wherein the prepolymer solution comprises a methacryloyl-substituted gelatin, a visible light activated photoinitiator, and a pharmaceutically acceptable carrier, wherein the methacryloyl-substituted gelatin has a degree of methacryloyl substitution between about 30% and about 85%, wherein the prepolymer solution comprises about 5% to about 25% (w/v) of the methacryloyl-substituted gelatin, wherein the prepolymer solution further comprises at least one corneal cell or a therapeutic agent, and wherein the methacryloyl-substituted gelatin comprises methacrylamide substitution and methacrylate substitution, and a ratio of methacrylamide substitution to methacrylate substitution is between 80:20 and 99:1.
Dependencies are inferred from the claim text.