Method for coating implant using heat

A method for coating a breast implant for the reconstruction of breast or aesthetic augmentation, the method comprising:

• allowing a thermal initiator and a first crosslinking agent to adsorb onto the implant and then drying the thermal initiator and the first crosslinking agent adsorbed on the implant, wherein the thermal initiator is selected from the group consisting of benzoyl peroxide (BPO), lauroyl peroxide, tert-butyl hydroperoxide, and cumene hydroperoxide (CHP);
• and
• after drying, adding a solution comprising an acrylate group-containing amphoteric monomer and a second crosslinking agent to the implant adsorbed with the thermal initiator and the first crosslinking agent and applying heat thereto,
• wherein the implant comprises a surface material selected from the group consisting of polydimethylsiloxane (PDMS), hydroxyapatite (HA), polylactic acid (PLA), polyglycolic acid (PGA), polytetrafluoroethylene (PTFE), polyethylene terephthalate (PET), polypropylene, polyamide, polyacetal, polyester, and polymethyl methacrylate,
• wherein the coating is formed by covalent bonds between acrylate groups of the acrylate group-containing amphoteric monomer and the surface material of the implant,
• wherein the coating provides strong hydrogen bonds with water molecules via its cationic and anionic charges to form a hydrated layer,
• wherein the concentration of the second crosslinking agent within the solution ranges from 0.01 mol % to 2.0 mol % relative to the amphoteric monomer,
• wherein heat is applied for 1 to 18 hours,
• wherein the first crosslinking agent and the second crosslinking agent are different and each independently selected from the group consisting of dipentaerythritol pentaacrylate, dipentaerythritol hexaacrylate, ethyleneglycol dimethacrylate, and a combination thereof,
• wherein the thermal initiator is used in an amount of 20 mol % to 50 mol % based on the acrylate group-containing amphoteric monomer,
• wherein the acrylate group-containing amphoteric monomer comprises at least one monomer selected from the group consisting of methacryloyloxyethyl phosphorylcholine (MPC), acryloyloxyethyl phosphorylcholine (APC), and carboxybetaine acrylate, and
• wherein the heat is applied at a temperature of 60° C. to 95° C.