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US 12,697,395 B2Granted
Slow-release cytokine conjugates
AssigneeProLynx LLC
InventorsJohn A. Hangasky, III, Samuel J. Pfaff, Daniel V. Santi
Life of this patent
Estimating the term…
Abstract
This disclosure generally relates to releasable cytokine conjugates and methods of using the same.
Claims18
A hydrogel of the formula
- wherein:
- M is a macromolecular carrier;
- q is an integer from 1 to 10 when M is a soluble macromolecular carrier or q is a multiple number in a suitable ratio to M when M is an insoluble macromolecular carrier;
- Z* is a connecting group comprising an amide, oxime, triazole, thioether, thiosuccinimide, or ether;
- n is an integer from 0 to 6;
- R1 is-CN, —NO2, —COR5, —SOR5, or —SO2R5, wherein R5 is C1-C6 alkyl, aryl, heteroaryl, or NR62, wherein each R6 is independently C1-C6 alkyl, aryl, or heteroaryl, and wherein R5 and R6 are independently optionally substituted;
- R2 is H or alkyl;
- each R4 is independently H or C1-C3 alkyl or the two R4 are taken together with the carbon atom to which they attach to form a 3-6 membered ring;
- S is absent or (CH2CH2O)h(CH2)gCONH wherein g=1-6 and h=0-1000;
- Y is NH (CH2CH2O)p(CH2)m wherein m=2-6 and p=0-1000;
- and
- D is an interleukin-15 (IL-15) or a fusion protein of interleukin-15 with an interleukin-15 Rα sushi domain (IL-15·IL-15RαSu).
9 more elements
A hydrogel comprising repeating units of the formula:
- wherein:
- P1 and P2 are independently r-armed polymers wherein r is an integer from 2 to 8;
- A* is a connecting group comprising carboxamide, oxime, ether, thioether or triazole;
- C* is a connecting group comprising carboxamide, oxime, ether, thioether or triazole;
- each n is independently an integer from 0 to 6;
- x, y, and z are independently an integer from 0 to 6;
- R11 is-CN, —NO2, —COR5, —SOR5, or —SO2R5, wherein R5 is C1-C6 alkyl, aryl, heteroaryl, or NR62, wherein each R6 is independently C1-C6 alkyl, aryl, or heteroaryl;
- R12 is H or alkyl;
- each R14 is independently C1-C3 alkyl or the two R14 are taken together with the carbon atom to which they attach to form a 3-6 membered ring;
- Z* is a connecting group comprising a carboxamide, amide, oxime, triazole, thioether, thiosuccinimide, or ether;
- S is absent or (CH2CH2O)h(CH2)gCONH wherein g=1-6 and h=0-1000;
- Y is NH (CH2CH2O)p(CH2)m wherein m=2-6 and p=0-100;
- R1 is —CN, —NO2, —COR5, —SOR5, or —SO2R5, wherein R5 is C1-C6 alkyl, aryl, heteroaryl, or NR62, wherein each R6 is independently C1-C6 alkyl, aryl, or heteroaryl;
- R2 is H or alkyl;
- each R4 is independently H or C1-C3 alkyl or the two R4 are taken together with the carbon atom to which they attach to form a 3-6 membered ring;
- and
- D is an IL-15 or an IL-15·IL-15RπSu fusion protein.
14 more elements
Dependencies are inferred from the claim text.